jurkat cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16133	MRK-560		Gamma-secretase
	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.		Gamma-secretase
T9079	Apostatin-1	Apt-1	Others
	Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.		Others
T3884	Neoandrographolide	Neoandrographiside	NOS , COX
	Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result from inhibition of iN...		NOS , COX
T37558	Necrostatin-5	Nec-5	RIP kinase , Necroptosis
	Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.		RIP kinase , Necroptosis
T35569	CTA 056		Apoptosis
	CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel...		Apoptosis
TL0013	Heraclenin		Anti-infection , Immunology/Inflammation related
	Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Her...		Anti-infection , Immunology/Inflammation related
T16075	(Rac)-Idroxioleic acid	2-Hydroxyoleic acid,2-OHOA,Minerval	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.		Apoptosis
T1847	Necrostatin-1	Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T61202	TDO-IN-1		Others
	TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune t...		Others
T39342	4-Maleimidosalicylic acid
	4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells.
TN4131	Germanicol acetate		Others
	Germanicol acetate shows some slight cytotoxic activity against Jurkat cells .		Others
T73149	HPK1-IN-33
	HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel...
TN4266	Isobonducellin		Antifection
	Isobonducellin exhibits potent cytotoxic activity in Jurkat and HepG2 cells, while moderate growth inhibition against Colon205 cells.		Antifection
T80497	KTX-Sp2		Potassium Channel
	KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3 channel and suppresses Ca2+ signaling in Jurkat T cells. Ad...		Potassium Channel
T36286	Protease-Activated Receptor-3 (PAR-3) (1-6), human
	TFRGAP-amide, human PAR-3-derived tethered ligand sequence which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells.
T12203L	Necrostatin 2		Others
	Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.		Others
T81394	PRO-HD1		HDAC
	PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50 of 5.8 µM [1].		HDAC
T14003	15-Acetoxyscirpenol		Caspase
	15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activat...		Caspase
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human...
T72586	Lck Inhibitor III
	Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM. Additionally, this compound effectively inhibits IL-2 synthesis in Jurkat cells, demonstrating an IC50 of 1.270 μM.